Issue 9/2026 · No. 438

A critical overview of the evidence behind the best-known plant-based longevity actives — from resveratrol to spermidine. What is proven, and what remains marketing?

Why the dose on the front of the pack rarely matches the dose in the studies — and which details on a label actually decide whether a formula can work.

Current research findings reveal how closely gut flora, inflammation and biological age are interconnected — and what you can do about it.

In this issue we focus on the theme of everyday longevity. Plus: New findings on Vitamin D, a portrait of the researchers rewriting the biology of aging, and the most-hyped anti-aging supplements put to the fact-check.
Our science editorial team continuously reviews current publications from the most prestigious medical journals. We consider the following studies especially relevant for healthspan and longevity — for healthcare professionals and curious readers alike.
A meta-analysis of over 47,000 participants shows that just 7,000 steps per day significantly lowers mortality risk — regardless of age or pre-existing conditions.
A 12-year prospective cohort study confirms that a consistently Mediterranean diet offers measurable protection against the development of type 2 diabetes mellitus.
Researchers at Johns Hopkins in Baltimore demonstrate that gut flora composition significantly influences checkpoint inhibitor response rates — a breakthrough for personalized oncology.
A long-term study from the Mayo Clinic in Rochester with 88,000 participants shows that chronically poor sleep increases the risk of heart attack and stroke by up to 45 percent — even in otherwise healthy individuals.
The VITAL study with over 25,000 participants reveals a surprising finding: in individuals without a documented deficiency, routine vitamin D supplementation offers no benefit for bone health.
The good physician treats the disease; the great physician treats the patient who has the disease.
— Sir William Osler (1849–1919), Father of Modern Clinical Medicine
Editor-in-Chief of longevitymag since 2009. Previously held a long-term position at Mount Sinai Hospital in New York. Her focus areas: prevention, healthy aging, and evidence-based health communication.

Member of the scientific advisory board since 2014. Regularly writes about supplement safety, interactions, and dosage evidence from his base in Boston.

Pharmacist and science journalist based in Chicago. Reports for longevitymag on the longevity industry, health policy, and the people behind the formulas.
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